| 摘要: |
| 目的:分析宫颈癌机会性筛查人群中高危型HPV感染情况及其与宫颈病变的关系。方法:统计2015年6月至2016年11月于北京大学第三医院行宫颈癌机会性筛查人群中HPV 16型、18型及其他12种HPV亚型的阳性率,计算高危型HPV阳性转诊阴道镜人群中发生CINⅡ及以上(CINⅡ~+)的比率及CINⅡ~+人群中HPV的感染构成情况。结果:宫颈癌机会性筛查人群中,高危型HPV总阳性率为19.0%,HPV 16阳性率为5.0%,HPV 18阳性率为1.6%,其他12种HPV阳性率为15.2%。HPV 16阳性、HPV 18阳性及其他12种HPV阳性患者TCT分流检测≥ASCUS者均转诊阴道镜病理活检,其发生CINⅡ~+的比率依次为55.2%、35.5%及38.9%;发生CINⅢ及以上(CINⅢ~+)的比率依次为25.3%、7.7%及6.9%。CINⅡ~+中45.0%为其他12种HPV感染、46.3%为HPV16感染、8.7%为HPV 18感染,其余病例为HPV阴性。结论:宫颈癌机会性筛查人群中,CINⅡ~+患者HPV 18阳性所占比率较低,其他12种HPV阳性所占比率高。需对各亚型阳性率进行细致分型以协助评估发病风险。转诊阴道镜人群中,HPV 18阳性者及其他12种HPV阳性患者TCT检查为ASCUS/LSIL者发生CINⅡ~+风险相对较低,可考虑通过行分流检测以提高筛查的特异性。 |
| 关键词: 宫颈癌筛查 人乳头瘤病毒 HPV分型检测 |
| DOI： |
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| Relationship between High-risk HPV Infection and Cervical Lsesions in Cervical Cancer Opportunistic Screening |
| HAN Qin;GUO Hongyan;GENG Li |
| (The Third Hospital of Peking University) |
| Abstract: |
| Objective:To analyze the infection rate of high-risk HPV(hr-HPV) and its relationship with cervical intraepithelial neoplasms in cervical cancer screening population. Methods:The positive rate of HPV 16,18 and other 12 kinds of HPV subtypes from 2015.Jun to 2016 Nov was calculated and the infection rate in CINⅡ~+ population were analysed.Results:In the cervical cancer screening population,the total HPV positive rate was 19. 0%,the positive rate of HPV 16,HPV 18 and other 12 kinds of HPV were 5. 0%,1. 6% and 15. 2% respectively The risk to develop CINⅡ~+ in HPV 16,HPV 18 and 12 other hr-HPV positive TCT ASCUS/LSIL population was 55. 2%,35. 5% and 38. 9% respectively The risk to develop CINⅢ~+ was 25. 3%,7. 7% and 6. 9% in HPV 16,HPV18 and other 12 kinds of hr-HPV positive TCT ASCUS/LSIL population respectively In the CINⅡ~+ population,45. 0% cases were 12 other hr-HPV positive while 46. 3% were HPV 16 positive and the positive rate of HPV 18 was 8. 7%.Conclusions:In the cervical cancer screening population,the rate of HPV 18 positive was low,the rate of other 12 kinds of HPV positive was high.It’s necessary to establish exact classification for the positive rate of each subtype.hr-HPV genotyping plays an important role in cervical cancer screening.In the referral to colposcope population,the rate of HPV 18 positive was low,the TCT results showed ASCUS/LSIL risk of HPV 18 positive and other 12 kinds of HPV positive was low.Consider using shunt detection to improve screening specificity. |
| Key words: Cervicalcancerscreening Humanpapillomavirus Humanpapillomavirusgenotypingtest |
