| 摘要: |
| 目的:探讨新鲜周期和玻璃化冻融周期卵裂期胚胎移植的围生期结局,评估玻璃化冻融方法的安全性和有效性。方法:回顾性分析重庆市妇幼保健院遗传与生殖研究所2010年1月至2015年12月出生儿随访数据,分别比较6786例玻璃化冻融周期和14672例新鲜周期单胎出生儿和双胎出生儿的围生期结局,包括流产、孕龄、早产、出生体质量和出生缺陷情况。结果:对于单胎分娩,在生产方式、平均孕龄和极早产率(孕龄<32周)方面两组比较,两组差异无统计学意义(P>0.05);新鲜周期组的早产率高于玻璃化冻融周期组(12.42%vs 7.66%,P<0.05),玻璃化冻融周期组新生儿平均出生体质量明显高于新鲜周期组(3349.63 g vs 3265.37 g,P<0.05)。对于双胎分娩,在生产方式、平均孕龄、早产率、极早产率和平均出生体质量方面比较,两组差异无统计学意义(P>0.05);新鲜周期组的低出生体质量比率明显高于玻璃化冻融周期组(P<0.05)。无论单胎分娩还是双胎分娩,两组的围生期死亡率和出生缺陷发生情况差异无统计学意义(P>0.05)。结论:在围生期结局方面,无论单胎分娩还是双胎分娩,玻璃化冻融对卵裂期胚胎并未增加负性影响。 |
| 关键词: 胚胎移植 玻璃化冻融 围生期结局 出生缺陷 |
| DOI： |
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| 基金项目:重庆市卫生局医学科研项目(编号:20142102) |
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| Comparison of Perinatal Outcomes after Fresh Versus Vitrified-Warmed Cleavage Stage Embryo Transfer |
| LIU Weiwei;HAN Wei;XIONG Shun;HUANG Guoning |
| (Chongqing Maternity Hospital,Chongqing Reproductive and Genetics Institute) |
| Abstract: |
| Objective: To evaluate the safety and efficacy of vitrification by comparing the perinatal outcomes of fresh transfers with vitrified-warmed transfers of cleavage stage embryos.Methods: The perinatal outcomes( miscarriage,gestational age,preterm delivery,live birth weight and birth defect) of singleton or twin delivery babies in vitrified-warmed cleavage stage embryo transfer group( 6786 cases) and fresh embryo transfer group( 14672 cases) were compared and analyzed. Results: For singleton deliveries,the delivery mode,mean gestational age and rate of very preterm birth( <32 weeks) did not differ significantly between two groups.Preterm birth occurred more often with fresh than with vitrified transfer( 12. 42% vs 7. 66%),and the mean birth weight of neonates from vitrified embryo transfers was significantly higher than from fresh ones( 3349. 63 g vs 3265. 37 g).For twin deliveries,there have no differences in delivery mode,mean gestational age,rate of preterm birth,rate of very preterm birth or mean birth weight.Perinatal mortality and the incidence of birth defects were similar in two transfer groups.Conclusions: Vitrification of cleavage stage embryos does not seem to have any adverse effects on perinatal outcomes. 更多 |
| Key words: Embryotransfer Vitrification Perinataloutcome Birthdefect |
