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妊娠期女性血小板数量与功能的相关性研究
李杨;王秋实;
0
(中国医科大学附属盛京医院)
摘要:
目的:探讨妊娠期女性不同水平血小板(PLT)计数与血栓弹力图(TEG)参数及其他凝血参数的相关性,以期发现妊娠期女性PLT计数与功能的内在关系,为临床建立妊娠期PLT功能评估和处理方案提供依据。方法:选择2014年10月至2016年3月的妊娠期女性200例,检测PLT计数、TEG各参数及凝血功能水平,应用Spearman检验分析PLT计数与各TEG参数之间的相关性以及其他凝血参数的相关性。结果:与PLT计数呈正相关的TEG参数有血凝块最大振幅(MA)(r=0.756,P<0.01)、血凝块形成速度(Angle)(r=0.626,P<0.01)、凝血综合指数(CI)(r=0.635,P<0.01);呈负相关的参数为血凝块形成时间(K)(r=-0.695,P<0.01);记录反应时间(R)、活化部分凝血活酶时间(APTT)及凝血酶原时间(PT)与PLT计数无相关性。PLT轻度缺乏组(PLT计数70×10~9/L~135×10~9/L)及PLT低值组(PLT计数135×10~9/L~200×10~9/L)PLT计数与MA及CI呈正相关,PLT低值组及PLT高值组(PLT计数>200×10~9/L)PLT计数与Angle呈正相关,PLT轻度缺乏组、PLT低值组及PLT高值组PLT计数与K呈负相关,PLT重度缺乏组(PLT计数30×10~9/L~70×10~9/L)PLT计数与纤维蛋白原(Fg)呈负相关,其余各组PLT计数与TEG各参数、常规凝血参数之间均无相关性。结论:PLT计数与MA、Angle及CI呈显著正相关;妊娠期女性PLT处于极低值的患者中,PLT计数不能充分反映其聚集功能,MA更能敏感地反应PLT功能。
关键词:  血栓弹力图  妊娠  血小板  凝血功能
DOI:
基金项目:辽宁省省直医院改革重点临床科室诊疗能力建设项目(编号:LNCCC-D13-2015)
Research of Correlation between Platelet Function and Count of Pregnancy
LI Yang;WANG Qiushi
(Shengjing Hospital of China Medical University)
Abstract:
Objective:To discuss the correlation between platelet count and thrombelastogram(TEG) parameters on pregnancy whose platelet count on the various levels,in order to find the intrinsic relations of platelet function and count,to provide the basis of the function evaluation of PLT during pregnancy and treatment.Methods:The PLT count,TEG parameters and coagulation function were tested in 200 pregnancy women from October 2014 to March 2016.Spearman test was used to analyze the correlation between the platelet count TEG parameters and coagulation function.Results:The TEG parameters which were positively correlatd with PLT count included MA(r =0.756,P<0.01),Angle(r = 0.626,P<0.01),CI(r = 0.635,P<0.01);The TEG parameters which were negatively correlatd with PLT count was K(r =-0.695,P<0.01);The TEG parameters which were not correlatd with PLT count included R、APTT、PT.In the mild lack of platelet group(PLT count 70×10~9/L-135×10~9/L) and the low value group(PLT count 135×10~9/L-200 × 10~9/L),platelet count was positive correlated with MA and CI,In the low value group and the high value group(PLT count>200×10~9/L),platelet count was positive correlated with Angle.In the mild lack of platelet group,the low value group and the high value group,platelet count was negatively correlated with K,In the severe lack of platelet group(PLT count 30×10~9/L-70×10~9/L),platelet count was negatively correlated with Fg.In the other group,there was no significant correlation between platelet count and TEG parameters、blood coagulation parameters.Conclusions:Platelet count was significantly correlated with MA,Angle and CI;But on the pregnancy with platelet count was extreme low value and high value,platelet count can not reflect the aggregation function,MA can more sensitively reflectthe platelet function.
Key words:  Thrombelastogram  Gestation  Platelet  Coagulation

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