| 摘要: |
| 目的:探讨不同孕期、不同季节孕妇25羟维生素D[25-hydroxyvitamin D,25(OH)D]水平及其与新生儿生长发育的相关性,为指导孕妇及时补充维生素D提供理论依据。方法:选择2015年6月至2016年5月在我院产科及内分泌科就诊的孕妇1255例,将其分为妊娠早期组(≤12周)224例、妊娠中期组(12~28周)642例、妊娠晚期组(≥28周)389例。按抽血测定25(OH)D时间,分为冬春季(2015年12月至2016年5月)648例、夏秋季(2015年6月至2015年11月)607例。通过测定孕妇的25(OH)D,评估不同孕期及不同季节维生素D缺乏[25(OH)D<30 nmol/L],维生素D不足[25(OH)D 30~50 nmol/L]、维生素D充足[25(OH)D≥50 nmol/L]状况及其与新生儿生长发育的相关性。结果:随着妊娠早、中、晚期进食鱼虾、鸡蛋、瘦肉量及进食奶制品量逐渐增加(P<0.01),妊娠早、中、晚期孕妇25(OH)D水平逐渐增加(31.81±11.71 nmol/L,34.77±15.89 nmol/L,37.19±16.66 nmol/L),妊娠早期25(OH)D水平低于妊娠中期和晚期(P<0.05),妊娠中期25(OH)D水平低于妊娠晚期(P<0.05)。1255例孕妇中维生素D缺乏511例,占40.7%。妊娠早、中、晚期维生素D缺乏比例分别为43.8%、43.0%、35.2%。在妊娠各时期夏秋季25(OH)D水平均高于冬春季(P<0.01)。孕妇的25(OH)D水平与新生儿体质量、身长、头围及出生后即刻、5分钟、10分钟的Apgar评分无明显相关性(P>0.05)。结论:维生素D缺乏在未服用维生素D补充剂的孕妇中比较普遍,尤其是妊娠早期,因此,应及早监测25(OH)D水平,以便尽早补充。孕妇的25(OH)D水平与新生儿生长发育无明显关系。 |
| 关键词: 维生素D缺乏 妊娠 新生儿 |
| DOI： |
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| 基金项目:2017年度江苏省妇幼健康科研项目(编号:F201720) |
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| Analysis of the Levels of 25 Hydroxyvitamin D of Pregnant Women in Different Trimester and Different Seasons and Its Correlation with Neonatal Growth and Development |
| PAN Ying;WANG Caibo;SHEN Jie |
| (The First People’s Hospital of Kunshan;School of Public Health,Medical College of Soochow University) |
| Abstract: |
| Objective: To evaluate the level of vitamin D in pregnant women in different trimester and different seasons and its correlation with neonatal development and growth.To provide theoretic foundation on vitamin D supplements for pregnant women.Methods: 1255 pregnant women visiting obstetric and endocrinology department from June 2015 to July 2016 were selected for the study.All these pregnant women were divided into the first trimester group( ≤12 weeks,n = 224),the second trimester group( 12-28 weeks,n = 642) and the third trimester group( ≥28 weeks,n = 389).These pregnant women were divided into two groups according to blood testing season: winter and spring group( n = 648),summer and autumn group( n = 607).The serum 25( OH) D concentrations were detected and Vitamin D status was grouped according to deficiency [25( OH) D<30 nmol/L],insufficiency[25( OH)D 30-50 nmol/L],and sufficiency[25( OH) D≥50 nmol/L].The correlation between Vitamin D status and neonatal development was evaluated.Results: With the gradually increased intake of fish,shrimp,eggs,lean meat and dairy products as gestation advanced,the level of 25-hydroxyvitamin D increased( P < 0. 01) as 31. 81 ± 11. 71 nmol/L,34. 77 ± 15. 89 nmol/L and 37. 19 ± 16. 66 nmol/L in first,second and third trimester,respectively. The25-hydroxyvitamin D concentration during the first trimester was significantly lower than that in the next two trimesters( P<0. 05). The 25-hydroxyvitamin D concentration during the second trimester was lower than that in the third trimester( P<0. 05).There were 511 cases( 40. 7%) of vitamin D deficiency in 1255 pregnant women.with43. 8%,43. 0% and 35. 2% in each trimester respectively.The 25-hydroxyvitamin D concentration in summer and autumn was significantly higher than that in spring and winter in all trimesters( P<0. 01).No association was observed between 25-hydroxyvitamin D level and birth length,birth weight,head circumference,Apgar score at 0 min,5 min or 10 min( P>0. 05).Conclusions: Vitamin D deficiency during pregnancy was prevalent in women who did not use supplementation.The deficiency of 25( OH) D among women in the first trimester of pregnancy was more serious.In order to provide supplements as soon as possible,detection of 25( OH) D should be performed in the first trimester.The levels of 25( OH) D in pregnant women were not significantly related to neonatal growth and development. |
| Key words: VitaminDdeficiency Pregnancy Newborn |
