| 摘要: |
| 目的:探讨生殖道人乳头瘤病毒(HPV)感染与阴道混合性感染之间的相关危险因素。方法:对2015年6月至2016年10月就诊于西安交通大学第一附属医院妇科门诊,同时行阴道微生态及HPV分型检测的1914例患者的检查结果并进行分析。结果:1914例患者中,HPV感染率28.00%(536/1914)。1378例未感染HPV者中阴道感染性疾病发生率为55.88%(770/1378),536例HPV感染者中阴道感染性疾病的发生率为65.30%(350/536),HPV感染者较未感染者阴道感染性疾病的发生率高(P<0.05)。阴道微生态正常者HPV感染率为25.26%(97/384),阴道混合性感染者HPV感染率33.86%(64/189),阴道混合性感染者HPV感染率较阴道微生态正常者高(P<0.05)。以阴道微生态正常者为对照(OR=1),阴道混合性感染与HPV感染间的OR1=1.515(95%CI 1.037~2.213)。阴道微生态正常者HPV16/18感染率为7.55%(29/384),阴道混合性感染者HPV16/18感染率为17.99%(34/189),混合性感染者较阴道微生态正常者高(P<0.05)。以阴道微生态正常者为对照(OR=1),阴道混合性感染与HPV16/18感染间的OR2=2.685(95%CI 1.580~4.563)。结论:阴道混合性感染可增加HPV及HPV16/18的感染率,特别是可以增加HPV16/18的感染率。 |
| 关键词: 阴道微生态 人乳头瘤病毒 阴道混合性感染 多样性 |
| DOI： |
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| 基金项目:陕西省科技统筹创新计划(编号:2016KTCL03-06) |
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| Risk Factors of Genital Tract HPV Infection and Vaginal Mixed Infection |
| MENG Lingting;GAO Li;YUE Ting |
| (First Hffiliated Hospital of Xi’an Jiaotong University;Northwest Women’s and Children’s Hospital;Shanxi Provincial People’s Hospital) |
| Abstract: |
| Objective: To explore the relationship between vaginal mixed Infection and HPV infection.Methods: Data from 1914 outpatients who underwent the vaginal micro-ecology and HPV type detection during June 2015 to October 2016 were collected and analyzed in the first affiliated hospital of Xi’an Jiaotong university.Results: HPV positive rate in 1914 cases was 28%( 536/1914).The incidence of vaginal infectious disease in 1378 HPV uninfected patients was 55. 88%( 770/1378),while the incidence in 536 HPV infected patients was 65. 30%( 350/536),the incidence of vaginal infectious disease was higher in HPV infected patients( P < 0. 05). HPV infection rate was25. 26%( 97/384) in normal vaginal microecology,use normal vaginal microecology as controls,OR = 1,HPV infection rate was 33. 86%( 64/189) in vaginal mixed infection,χ2= 4. 639,OR1= 1. 515( 95% CI 1. 037-2. 213),HPV infection rate in mixed infection patients were significantly higher than in normal vaginal microecology( P <0. 05); Of 91 cases high-risk type HPV infection in normal vaginal microecology,HPV16 and HPV18 infection account 31. 87%( 29/91),the positive rate was 7. 55%( 29/384),use normal vaginal microecology as controls,OR = 1,59 cases high-risk type HPV infection were found in vaginal mixed infection patients,HPV16 and HPV18 infection account 57. 62%( 34/59),the positive rate was 17. 99%( 34/189),χ2= 14. 100,OR2= 2. 685( 95% CI1. 580-4. 563).Conclusions: The vaginal mixed infection can increase the HPV infection rate,especially for HPV16 or HPV18. |
| Key words: Vaginalmicroecological Humanpapillomavirus Mixedinfection Diversity |
